Magnesi Trisilicat

Magnesi Trisilicat

Giá: Liên hệ
Tình trạng kho: còn hàng

Mô tả

Hạn dùng: 60 tháng
Quy cách:Túi 15;20kg
Công thức:Mg2Si3O8.xH2 O
Tiêu chuẩn:DÐVN III

 1.     Các loại tên và công thức của thành phẩm.Danh pháp IUPAC : dimagnesium 2,2,6,6-tetraoxido-1,3,5,7-tetraoxa-2,4,6-trisilaspiro[3.3]heptane hydrate.

-         Tên gọi khác : Magnesium trisilicate (hydrate).
-         CAS number : [ 39365-87-2 ].
-         Công thức phân tử : Mg2O8Si3.xH2O.

 2.     Tính chất vật lý.

-         Khối lượng mol phân tử : 260.862 g/mol.
-         Tồn tại ở dạng tinh thể màu trắng, độ nhớt cao, có mùi dịu.
-         Khối lượng riêng : 200 - 600 kg/m3 (tùy theo mức độ hydrate hóa).
-         Độ tan : Không tan trong nước.

 3.     Ứng dụng.
- Trong y học, Magnesium Trisilicate hydrate được chỉ định điều trị trạng thái cao axit dạ dày (loét dạ dày, ợ chua do thừa acid dịch vị), dùng với một số thuốc có hại với dạ dày để triệt tiêu tác hại.
- Dược lý và cơ chế tác dụng: Magie trisilicat tan trong acid dịch vị, giải phóng ra các anion có tác dụng trung hòa acid dạ dày, hoặc làm chất đệm cho dịch dạ dày, nhưng không tác động đến sự sản sinh ra dịch dạ dày. Kết quả là pH dạ dày tăng lên, làm giảm triệu chứng tăng acid. Thuốc cũng làm giảm độ acid trong thực quản và làm giảm tác dụng của men pepsin. Tác dụng này đặc biệt quan trọng ở người bệnh loét tiêu hóa. pH tối ưu của hoạt động pepsin là 1,5 - 2,5; do antacid làm tăng pH dạ dày lên trên 4, nên tác dụng phân giải protein của pepsin là thấp nhất.
- Dược động học: Magie trisilicat phản ứng tạo thành magie clorid, silic dioxyl, và nước. Khoảng 15 - 30% lượng magie clorid vừa tạo ra được hấp thu và sau đó được thải trừ qua nước tiểu ở người có chức năng thận bình thường. Còn lượng magie hydroxyl nào mà chưa chuyển hóa thành magie clorid thì có thể được chuyển hóa ở ruột non và được hấp thu không đáng kể.
- Chỉ định: Magie trisilicat được dùng bổ trợ cho các biện pháp khác để giảm đau do loét dạ dày - tá tràng và để thúc đẩy liền loét.
- Thuốc cũng được dùng để giảm đầy bụng do tăng acid, ợ nóng, khó tiêu và ợ chua (trào ngược dạ dày - thực quản).
- Được dùng làm thuốc chống axit trong dịch vị.

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